But Kobeissi says he was startled by the level of interest in the concept. “I posted that tweet and the expectation that I had was that basically 60 people max would retweet it and then maybe I’ll set up a Kickstarter,” he tells us. Instead the tweet “just completely exploded” and he found himself raising $100k “in a single day” - with $50k paid in there and then. I’ve been running a business based on consulting and based on academic R&D services,” he continues. “But by the end of the day - last Sunday, eight days ago - I was running a Delaware corporation valued at $10M with $100k in pre-seed funding, which is insane. Completely insane.”Ĭapsule is just the latest contender for retooling Internet power structures by building infrastructure that radically decentralizes social platforms to make speech more resilient to corporate censorship and control. The list of decentralized/p2p/federated protocols and standards already out there is very long - even while usage remains low. ![]() Interest in the space has been rekindled in recent weeks after mainstream platforms like Facebook and Twitter took decisions to shut down US president Donald Trump’s access to their megaphones - a demonstration of private power that other political leaders have described as problematic.Įxtant examples include ActivityPub, Diaspora, Mastodon, p2p Matrix, Scuttlebutt, Solid and Urbit, to name a few. Kobeissi also takes that view, while adding the caveat that he’s not “personally” concerned about Trump’s deplatforming.
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![]() Now press OK to close the Project Properties dialog, and for each section document you want to omit from the sample, type ‘notsample’ into the Tags field. Type ‘notsample’ as the value for this option. Once the configuration has been created, search for ‘Exclude sections matching tags’ in the search field at the bottom of the dialog. Type ‘Epub Sample’ for the new configuration name, and select a configuration to base this one on, or just press OK to select a format. To get there, press Edit next to the configuration drop-down in the Jutoh Control Panel (bottom left of the Jutoh window). Create a new configuration called ‘Sample Epub’ using the ‘+’ button on the Configurations panel in Project Properties. Let’s say you wanted to be able to create a sample Epub. Open the document properties dialog using right click or control click over the project outline, or using the menu command Document | Document Properties (Shift+Alt+Enter). To include or exclude whole section documents, go the document properties and assign a tag name (or several tag names) to the Tags field. Tagging whole section and media documents Specifying paragraph styles to include or omit.Specifying string variables in your content.These are the different methods available to you for changing the book without editing content each time: The different values of options in your configurations will determine how the book is created. So to create your sample, you just select ‘Sample Epub’ and press Compile. You might have a ‘Sample Epub’ configuration that creates an ebook containing the first couple of chapters of your book. There are several ways of creating conditional content, suitable for different tasks or kinds of content, but they all depend on the fact that you can have multiple configurations, even for the same format. With Jutoh, you can do all this without needing to split your project into different copies, which can become a time-consuming, confusing mess. ![]() Or perhaps you need to include different audio or video media for different formats. Or you may need to add extra pages, blank or otherwise, for a print book. You may need different book identifiers, or different text describing where to buy the book, or perhaps you’d like to create a small sample for your web site that can be easily recreated when you update the book. Please see note at the bottom for an update.īy popular demand, this episode I’m going to show you how to create fixed layout eBooks in Jutoh.It’s common to want to create different versions of your book for different distributors, formats or purposes. ![]() It will also be EPUBs for Barnes & Noble, iTunes, et cetera. In this lesson I’m going to discuss how to create Kindle and EPUB fixed layout books using Jutoh. It’s been asked of me by several people so I decided to make a quick video for you. If you’re interested in Jutoh, which if you are an author or a publisher, if you’re still doing it the old-fashioned way, you’re crazy. The first thing you do is understand why you need a fixed layout book. If you just have a picture in there and the picture’s not that important, it’s not a big deal to make a fixed layout book. ![]() The text and the picture go exactly where you put them, and they lose a lot of the flexibility on eReaders, There’s a lot of issues with file sizes, picture sizes, all that kind of stuff, and there’s no software that’s really able to deal with that since it’s controlled by the actual devices themselves. I’ll show you an example of that when we’re done making this picture book. Many uses would be comic books, picture books, like I’m going to do here kids books that have a picture and then text underneath it, those type of things, where the picture needs to be exactly where it is in the book. It can’t just be random wherever the flowable layout puts it, like half of an image on one page and half on the other. I’m going to go a little bit from scratch. Somebody was asking me if you already know how to do projects and that, this will be nothing new. There’s only one slight change, so we’ll go up here to File, New Project. That was another client, but I’m going to erase this anyway. It’s automatically putting it where it needs to go. We saw that in the other videos I have, but for fixed layout I don’t bother. Normally, you just say Normal Reflowable Book. In this case we’re going to go to Fixed Layout. Jutoh makes it nice to actually have different book styles for different devices. We can go here to Page Templates and you can see Kindle Fire. We have not noticed any significant drawbacks of this app. They are a little bit outdated, but many people still find them useful.Īll in all, URL Manager Pro is a must-have tool for everyone. Discover a range of award-winning security, privacy & performance tools for all devices Antivirus VPN System Speedup Mobile & more. But if you have faced any difficulties while using this app, the developer provides responsive customer service.īy the way, you may also be interested in flash browser apps. Moving on, URL Manager Pro offers a convenient user experience. Besides, you can also backup copies of bookmark documents. The app supports an automatic saving at certain intervals. Download Not Available Your current device is not supported. Internet Download Manager (IDM) is a tool to increase download speeds by up to 5 times, resume or schedule downloads and download streaming videos. As for the other additional options, URL Manager Pro enables users to create bookmarks, add notes, create folders, move bookmarks to folders, copy URL, email and print bookmarks.Īnother interesting option- you can also export your bookmarks to HTML, XBEL, TEXT, and Internet Location files. Download Android Studio editor Android Gradle Plugin SDK tools Preview Android Studio Get the official Integrated Development Environment (IDE) for Android app development. Additionally, you can apply tags, notes, or colors to your bookmarks. URL Manager Pro allows you to manage your bookmarks with drag and drop. Plus, it is quite lightweight, so you will install it in a few seconds. We have to admit that this app works steadily without any lags. release page here and download the MSI installer file of the latest release. ![]() You may also want to try private browser apps. version manager built in Rust used to manage multiple released Node.js versions. But you can also use your bookmarks with any web browser – for example, Safari, Chrome, Edge, Chromium, Opera, Firefox, and so many others. URL Manager Pro is a full-featured application that allows you to manage your bookmarks independently from a web browser. WKAR Family and Impression 5 Science Centerĭaniel Tiger’s Neighborhood is produced by Fred Rogers Productions.ĭANIEL TIGER'S NEIGHBORHOOD © 2012, The Fred Rogers Company.
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Radio controlled wall clock: auto updates. ![]() mRNA encoding a therapeutic protein was reported in 1992 (Jirikowski et al., Science 255:996-998), but only recently has the delivery of mRNA for scientific and therapeutic purposes gained expanded interest.C12N2320/30- Special therapeutic applications.C12N2310/33- Chemical structure of the base.C12N2310/00- Structure or type of the nucleic acid.A61K48/00- Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases Gene therapy.A61K- PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES.A61- MEDICAL OR VETERINARY SCIENCE HYGIENE.C12P19/26- Preparation of nitrogen-containing carbohydrates.C12P19/00- Preparation of compounds containing saccharide radicals.C12P- FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE.C07K14/52- Cytokines Lymphokines Interferons.nucleic acids with ribosyl as saccharide radical C07H21/02- Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g.C07H21/00- Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g.C07H- SUGARS DERIVATIVES THEREOF NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS.C07K14/475- Growth factors Growth regulators.C07K14/435- Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof from animals from humans.C07K14/00- Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof.C12N15/85- Vectors or expression systems specially adapted for eukaryotic hosts for animal cells.C12N15/79- Vectors or expression systems specially adapted for eukaryotic hosts.C12N15/63- Introduction of foreign genetic material using vectors Vectors Use of hosts therefor Regulation of expression.plasmids, or their isolation, preparation or purification Use of hosts therefor C12N15/00- Mutation or genetic engineering DNA or RNA concerning genetic engineering, vectors, e.g.C12N- MICROORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA.C12- BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION OR GENETIC ENGINEERING.Assignors: WEISSMAN, DREW, KARIKO, KATALIN Status Abandoned legal-status Critical Current Links Assignors: UNIVERSITY OF PENNSYLVANIA Assigned to THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA reassignment THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). GOVERNMENT CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT reassignment NATIONAL INSTITUTES OF HEALTH (NIH), U.S. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn Priority to US14/776,525 priority Critical patent/US20160032316A1/en Publication of US20160032316A1 publication Critical patent/US20160032316A1/en Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), U.S. Original Assignee University of Pennsylvania Penn Priority date (The priority date is an assumption and is not a legal conclusion. ![]() Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Abandoned Application number US14/776,525 Inventor Drew Weissman Katalin Kariko Current Assignee (The listed assignees may be inaccurate. Google Patents Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosidesĭownload PDF Info Publication number US20160032316A1 US20160032316A1 US14/776,525 US201414776525A US2016032316A1 US 20160032316 A1 US20160032316 A1 US 20160032316A1 US 201414776525 A US201414776525 A US 201414776525A US 2016032316 A1 US2016032316 A1 US 2016032316A1 Authority US United States Prior art keywords another embodiment rna purified preparation cell messenger rna Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US20160032316A1 - Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides US20160032316A1 - Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides ![]() Also Enter correct values for subnet and default getway. Now go to Menu Network -> TCP/IP Go to IP Address selection You can’t change these settings if DHCP is ON Update IP Address to new ILP DNS entry.* Make sure DHCP is set to OFF (use spacebar to change the settings) Once system start booting… You will see white screen display “HP Proliant Servers ….” After this keep on pressing F8 key to get you into ILO configuration Screen. ![]() Connect Monitor to this machine (connect to front port, it’s easy!) and have keyboard connection at the back.In this case to debug the configuration, you need to connect that machine physically. After I tried to self sign it through OpenSSL in that way: openssl genrsa -aes256 -out rootCA.key 4096 openssl req -x509 -new -nodes -key rootCA.key -days 1024 -out rootCA.pem openssl x509 -req -in ilo.csr -CA rootCA.pem -CAkey rootCA. Then go to Users -> Modify user and change the ILO admin password which can help to get back to use ILO again.īut for some reasons if you haven’t configured ILO dns correctly, then you may not be able to access the ILO web interface. I created a CSR (ilo.csr) from iLO web interface -> Security -> SSL Certificate. Press F8 to enter into ILO Configuration. Make sure monitor and keyboard is connected to box and boot the machine. In a worst case scenario where you forgot the user id/ password for ILO login, then only way to reset the password is by connecting physically to the box. All the same settings from the POST utility can be configured through the ILO web interface Use the leased ip to access the web interface and login with the factory username and password. If DHCP is accessible from the ILO interface connected network then check the leases for the DNS name printed on the tag. Test access to the ILO web interface.Ĭhecking DHCP leases and configuration from the server OS are some alternate setup options if your server is already in production and the ILO settings were not configured beforehand. Select Exit to save and reset ILO with the new settings. Note that the username and password are both case sensitive. Next, set the Administrator password or create new user. Select Enter while the Set Defaults option is highlighted to revert back to factory settings.įirst, access the Network menu, disable DHCP and change the DNS name The menu is straightforward and self explanatory. The easiest way to access the ILO configuration utility is during the POST by pressing F8 when prompted. Printed on the tag is the server serial number and Integrated Lights Out access information including factory set username and password. Most brand new HP servers come with an information tag attached. How to configure and access ILO on a fresh out the box Proliant M元50 G5 server:įirst, connect the ILO designated network port to your switch or management network. Full graphical remote console redirection is available with the advanced license. Standard ILO features include remote shutdown and startup, virtual media, text mode console redirect and access to hardware logs, status and diagnostic tools. Having the ability to remotely access HP servers from POST to OS is an invaluable tool. ILO interface provides exact same interface as you will see when you have connected monitor, keyboard and mouse to each individual server. Idea is physically you don’t have to be in the data center to manage servers. ILO is a very cool feature that allows one to manage the server box remotely. ![]() Sometimes, delays happen due to festival, holidays, natural disasters, or carrier delays. In 90% of the cases, order is delivered on time, under normal circumstances. The above mentioned delivery time is estimated. The delivery time is guaranteed or estimated ? For Rest of India- After shipping, it takes 3-4 business days for the orders to get delivered. How many days does it takes for the order to get delivered ?įor Metro Cities- After shipping, it takes 2 business days for the orders to get delivered. ![]() Once the order is dispatched, we will send you an email and message with the tracking information. ![]() What is the estimated dispatch time? Order get dispatched in 3 working days from our warehouse. If 6hrs has alredy passed by and your order has been taken up for processing then, we shall not be able to cancel the order. For this, drop in a mail at and mention your order id. How to cancel my order? You can cancel your order within 6hrs. We accept multiple payment methods, you can choose to pay through Debit/Credit cards, Net-banking, UPI and wallets. You can also pay using Cash On Delivery, but using this method a COD charge of Rs.99 will be added to your order. When you place an order at Nautunkee, someone from our team will contact you, within 12 hrs. Once you place the order, you will receive an order confirmation email on your email id which you used during the checkout. How do I know if the order is successful? We encourage you to pay online in order to avoid a COD charge of Rs.99. Proceed to payment, you can select either online payments or cash on delivery. Proceed to checkout, fill your contact, email and shipping details. Once you have decided the products you love from our store, please select the color and your size according to the size guide and add it to cart. ![]() This improvement has been showing 10% faster load times for Windows and macOS users, and 20% faster for Linux users! We’ve also seen that it is decreasing the number of times the Python extension becomes unresponsive by 15% across the board. Our team has been working hard on improving stability and performance of the Python extension, and we are now thrilled to announce that starting in this release, the Python extension will be loading much faster and more reliably thanks to a major improvement on our Python environments discovery mechanism. ![]() You can also change your language server explicitly via the settings UI or in your settings.json. Once you uninstall Pylance, it won’t be installed again when the Python extension updates. If you’d like to use another language server (e.g., Jedi), you can uninstall or disable the Pylance extension at any point. We are committed to maintaining open-source language support options for our users in the future. This work has enabled us to further improve the performance and overall experience of other language servers, like the open-source Jedi language server (thanks to David Halter, Samuel Roeca and danixeee for their cooperation and partnership!). We’ve invested resources to standardize the way that language servers communicate with the Python extension (via Language Server Protocol). With this top of mind, our team has also been working to make language support better for everyone, regardless of your language server. ![]() However, we are committed to making sure that you can configure your development environment exactly how you like it. We believe that Pylance provides the very best user experience for Python development and we hope that you’ll try it out. This means that you’ll get the latest and greatest language support right out of the box with the Python extension (no separate install needed!). As of this release, we’ve included the Pylance extension as an optional dependency for the core Python extension. If you’ve been following along with our releases over the last year, we’ve been making dramatic improvements to Python language support via the Pylance extension. If you’re unfamiliar with Pylance, you can read more about its awesome features in the preview release announcement blog post. This upgrade provides what we believe is the most performant and user-friendly Python editing experience for Visual Studio Code ever. Today, we’re excited to announce that the Python extension’s default language support is now powered by Pylance. Upgraded language support, powered by Pylance If you’re interested, check out the full list of improvements in our changelog. Other notable updates are that we now have faster extension startup time and a new debugger feature: live reload for Python scripts. ![]() We’re thrilled to announce that Pylance is now the default language server for Python and is bundled with the core Python extension as an optional extension starting with this release. You can learn more about Python support in Visual Studio Code in the documentation. If you already have the Python extension installed, you can also get the latest update by restarting Visual Studio Code. You can download the Python extension from the Marketplace, or install it directly from the extension gallery in Visual Studio Code. We are pleased to announce that the May 2021 release of the Python Extension for Visual Studio Code is now available. ![]() The following items are prohibited from being shipped using DHL Express: Consult DHL's What Can I Ship webpage, and make sure you're familiar with your destination country's shipping regulations. Some items and commodities are restricted depending on where you're shipping to.
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