mRNA encoding a therapeutic protein was reported in 1992 (Jirikowski et al., Science 255:996-998), but only recently has the delivery of mRNA for scientific and therapeutic purposes gained expanded interest.C12N2320/30- Special therapeutic applications.C12N2310/33- Chemical structure of the base.C12N2310/00- Structure or type of the nucleic acid.A61K48/00- Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases Gene therapy.A61K- PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES.A61- MEDICAL OR VETERINARY SCIENCE HYGIENE.C12P19/26- Preparation of nitrogen-containing carbohydrates.C12P19/00- Preparation of compounds containing saccharide radicals.C12P- FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE.C07K14/52- Cytokines Lymphokines Interferons.nucleic acids with ribosyl as saccharide radical C07H21/02- Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g.C07H21/00- Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g.C07H- SUGARS DERIVATIVES THEREOF NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS.C07K14/475- Growth factors Growth regulators.C07K14/435- Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof from animals from humans.C07K14/00- Peptides having more than 20 amino acids Gastrins Somatostatins Melanotropins Derivatives thereof.C12N15/85- Vectors or expression systems specially adapted for eukaryotic hosts for animal cells.C12N15/79- Vectors or expression systems specially adapted for eukaryotic hosts.C12N15/63- Introduction of foreign genetic material using vectors Vectors Use of hosts therefor Regulation of expression.plasmids, or their isolation, preparation or purification Use of hosts therefor C12N15/00- Mutation or genetic engineering DNA or RNA concerning genetic engineering, vectors, e.g.C12N- MICROORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA.C12- BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION OR GENETIC ENGINEERING.Assignors: WEISSMAN, DREW, KARIKO, KATALIN Status Abandoned legal-status Critical Current Links Assignors: UNIVERSITY OF PENNSYLVANIA Assigned to THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA reassignment THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). GOVERNMENT CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT reassignment NATIONAL INSTITUTES OF HEALTH (NIH), U.S. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn Priority to US14/776,525 priority Critical patent/US20160032316A1/en Publication of US20160032316A1 publication Critical patent/US20160032316A1/en Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), U.S. Original Assignee University of Pennsylvania Penn Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Abandoned Application number US14/776,525 Inventor Drew Weissman Katalin Kariko Current Assignee (The listed assignees may be inaccurate. Google Patents Purification and Purity Assessment of RNA Molecules Synthesized with Modified NucleosidesÄownload PDF Info Publication number US20160032316A1 US20160032316A1 US14/776,525 US201414776525A US2016032316A1 US 20160032316 A1 US20160032316 A1 US 20160032316A1 US 201414776525 A US201414776525 A US 201414776525A US 2016032316 A1 US2016032316 A1 US 2016032316A1 Authority US United States Prior art keywords another embodiment rna purified preparation cell messenger rna Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US20160032316A1 - Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides US20160032316A1 - Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
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